352P - Functional status of central nervous system in intensive radiotherapy for brain metastases

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Central Nervous System Malignancies
Surgical oncology
Radiation oncology
Presenter Mikhail Zinkovich
Citation Annals of Oncology (2016) 27 (6): 103-113. 10.1093/annonc/mdw367
Authors M. Zinkovich1, O. Kit2, T. Protasova3, A. Pushkin3, Y. Arapova3, E. Korobeynikova3, A. Shikhlyarova3, L. Vladimirova4
  • 1Department Of Radiology, Rostov Research Institute of Oncology, 344037 - Rostov on Don/RU
  • 2Surgical Department, Rostov Research Institute of Oncology, 344037 - Rostov on Don/RU
  • 3Experimental Laboratory Center, Rostov Research Institute of Oncology, Rostov on Don/RU
  • 4Department Of Chemotherapy, Rostov Research Institute of Oncology, 344037 - Rostov on Don/RU



Combined treatment including whole brain irradiation (WBI) with additional boost has shown its advantages concerning overall survival of patients with solitary brain metastasis (SBM). However, the literature data on neurotoxicity and safety of additional local irradiation are ambiguous. The purpose of the study was to compare electrophysiological parameters of the functional state of the brain after WBI and WBI with additional boost to the bed of removed metastatic foci.


The study included 16 patients of each gender with SBM after the treatment of primary tumors. Parameters of EEG and electrical conductivity (EC) of auricular points (AP) were studied in two groups of patients receiving irradiation 3-4 weeks after metastasis removal: the control group (WBI) and the main one (WBI + boost). EEG was recorded monopolarly using Encephalan EEG-19/26, Russia (26 channels) from 19 electrodes according to the international 10–20 system. Power spectrum values before and after radiation therapy (RT) were compared using MANOVA. ECAP were studied using DiaDENS PC medical diagnostic system at the same RT stages.


The main group showed increased power values of &thgr; range by 6-9% (р 


EEG and electroacupuncture parameters showed the decrease in CNS functional activity during increased radiation exposure due to the additional boost. The data suggest the need for development of bioadaptive effects weakening the damaging effects of adjuvant RT in patients with brain metastasis.

Clinical trial identification

Legal entity responsible for the study

Rostov Research Institute of Oncology


Ministry of Health of the Russian Federation


All authors have declared no conflicts of interest.