545P - A retrospective study on prognostic value of preoperative neutrophil/lymphocyte ratio in patients with primary small cell carcinoma of the esophagus

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Oesophageal Cancer
Surgical oncology
Presenter Yan Wang
Citation Annals of Oncology (2016) 27 (suppl_9): ix177-ix178. 10.1093/annonc/mdw600
Authors Y.-. Wang
  • Thoracic Surgery, 4th Hospital Hebei Medical University, 050000 - Shijiazhuang/CN

Abstract

Background

There is increasing evidence that systemic inflammation influences the prognosis in patients with malignant tumors. The aim of this research was to investigate the prognostic value of neutrophil/lymphocyte ratio(NLR) in patients with primary small cell carcinoma of the esophagus.

Methods

We retrospectively analyzed 129 patients with primary small cell carcinoma of the esophagus underwent esophagectomy in our hospital between January 2008 and December 2010. NLR were calculated with the following formula: peripheral neutrophil count/lymphocyte count (109/L). Correlations of neutrophil-to-lymphocyte ratio with other clinicopathological data and prognosis were analyzed. The survival was calculated by Kaplan-Meier analysis. The differences between groups were compared using Log-rank test. Cox regression was used to analyze the factors which may affect the survival of the patients.

Results

The survival rate was found to be related to tumor stage, tumor location, nodal metastasis, TNM stage, histology, adjuvant therapy and NLR(all P 

Conclusions

Neutrophil-to-lymphocyte ratio is a valuable clinical marker in preoperative estimation as well as prognosis prediction for patients with primary small cell carcinoma of the esophagus.

Clinical trial indentification

Legal entity responsible for the study

Yan Wang

Funding

Hebei provincial health and Family Planning Commission

Disclosure

All authors have declared no conflicts of interest.