378PD - Impact and predictive factor of undertreatment of analgesic drug in outpatients with cancer: a nationwide of clinical pain survey in Taiwan

Date 21 December 2015
Event ESMO Asia 2015 Congress
Session Supportive and palliative care
Topics Supportive and Palliative Care
Presenter Chan-Keng Yang
Citation Annals of Oncology (2015) 26 (suppl_9): 111-124. 10.1093/annonc/mdv531
Authors C. Yang1, W. Chou2, W. Shen2, J. Chen2, K. Lee3, C. Yen4, P. Lai5, Y. Shao6, W. Hwang7, T. Chiou8, Y. Sung9, K. Rau10, Y. Liao11, C.S. Chang12, M. Wu13, M. Lee14, M. Yu15, T. Liu16, R. Hsieh17
  • 1Division Of Hematology-oncology, Department Of Internal Medicine, Chang Gung Memorial Hospital-Linkou, 333 - Taoyuan/TW
  • 2Division Of Hematology-oncology, Department Of Internal Medicine, Chang Gung Memorial Hospital-Linkou, Taoyuan/TW
  • 3Hematology And Oncology, Chiayi Chang Gung Memorial Hospital, Chiayi/TW
  • 4Hematology And Oncology, National Cheng Kung University Hospital, Tainan/TW
  • 5Hematology And Oncology, E-DA Hospital, Kaohsiung/TW
  • 6Oncology, National Taiwan University Hospital, Taipei/TW
  • 7Hematology And Oncology, Taichung Veterans General Hospital, Taichung/TW
  • 8Hematology And Oncology, Taipei Veterans General Hospital, Taipei/TW
  • 9Hematology And Oncology, Cathay General Hospital, Taipei/TW
  • 10Hematology And Oncology, Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung/TW
  • 11Hematology And Oncology, China Medical University Hospital, 404 - Taichung/TW
  • 12Hematology-oncology, Changhua Christian Hospital Cancer Research Center, Changhua City/TW
  • 13Oncology, Chung Shan Medical University Hospital Da-Ching, Taichung/TW
  • 14Hematology And Oncology, Chia Yi Christian Hospital, Chiayi/TW
  • 15Hematology And Oncology, Kaohsiung Veterans General Hospital, Kaohsiung/TW
  • 16Hematology And Oncology, Chung-Ho Memorial Hospital,Kaohsiung Medical University Hospital, Kaohsiung/TW
  • 17Hematology And Oncology, Mackay Memorial Hospital, Taipei/TW



This study is part of multi-center clinical survey on satisfaction of pain management in patients with cancer in Taiwan. The purpose was going to explore the impact of quality of life and factors relevant to undertreatment of analgesic agents in Taiwanese outpatients with cancer.


The outcome questionnaire of this study was based on the Brief Pain Inventory (BPI). The BPI asked patients to rate their current pain intensity and also pain in the last 7 days at its worst, least, and average. Patients were also asked to rate the extent to which their pain interfered with 7 quality of-life (QoL) domains, and to rate the satisfaction of pain control to the physician and the analgesic drugs. The Pain management index (PMI) was computed by subtracting the pain level from the analgesic level.


A total of 2,652 outpatients who age 20 or older diagnosed with cancer were enrolled. The mean age were 57 (range 20-95) years, while 56% were male. 62.6% patients had ever pain within last week at the time of assessment. 32.4% patients was the negative PMI. Patients with negative PMI score had significant poor outcome at all of 7 QoL domains (all p values < 0.001) and also had a significantly higher scale toward dissatisfaction of pain control to the physician (1.92 vs 1.73, p = 0.038) and to the analgesic drugs (1.96 vs 1.77, p = 0.039). Gender (female vs male: 55.9% vs 75.7%, odds ratio [OR] 0.41, 95% CI 0.33-0.50, p <0.001), primary tumor site (breast vs hematology: 45.5% vs 66.1%, OR 0.43, 95% CI 0.29-0.63, p <0.001), cause of pain (noncancer-related vs cancer-related: 58.1% vs 72.5%, OR 0.51, 95% CI 0.40-0.64, p <0.001) and hospital locations(south Taiwan vs north Taiwan: 76.5% vs 56.4%, OR 2.52, 95% CI 1.97-3.22, p < 0.001) were independent variables that predicated patients with positive PMI.


Patients with negative PMI had significant poor outcome at all of 7 QoL domains. In addition, negative PMI with a significantly higher scale toward dissatisfaction of pain control and the analgesic drugs. Patients who being female, breast cancer, noncancer-related pain, and patients at north Taiwan had the lower probability of being a positive PMI.

Clinical trial identification

Chang Gung Medical Foundation IRB: 102-5775B; 2014-3-28 to 2015-3-27


All authors have declared no conflicts of interest.