P-132 - The expression characteristics and clinical significance of Ki-67 in gastrointestinal stromal tumors

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics GIST
Pathology/Molecular Biology
Basic Scientific Principles
Presenter S. Tang
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors S. Tang1, B. Zhang2, Y. Yin1, C. Shen3
  • 1West China Hospital, Chengdu City/CN
  • 2Sichuan University, Chengdu/CN
  • 3West China Hospital, Chengdu/CN



To investigate the expression characteristics and clinical significance of Ki-67 in gastrointestinal stromal tumors.


Clinical features,immunohistochemiscal characteristics, treatment and follow-up data were retrospectively analyzed. A total of 97 patients with GIST in our institution between July 2012 and September 2013 were identified.


112 patients were enrolled in this study initially,15 patients being lost to follow-up.Complete follow-up and clinicopathology information of 97 patients could be acquired.30 (30.9%) out of 97 cases experienced tumor recurrence or distant metastasis,and 4 (4.1%) patients died. There were no statistically significant difference with respect to age and sex concerning Ki-67 expression (P > 0.05). The difference in tumor size, location,risk stratification, mitotic count was significant (P<0.05),and positive relation was observed between them and Ki-67 (rs>0). The expression of Ki-67 was more stronglyrelated to recurrence or metastasis of GIST compared to mitotic count with the values ofrs0.395,0.266 separately. Cox multivariate analysis indicated that both Ki-67 and mitotic count were independent factors for recurrence-free survival. Ki-67 influenced

the prognosis of medium-high risk patients in survival analysis.


Ki-67 was closely related to tumor size, risk stratification and mitotic count, and could

help to evaluate the prognosis of patients with GIST.