1207P - Prognostic factors in development of brain metastasis in stage III non-small cell lung cancer patients after definitive treatment

Date 29 September 2012
Event ESMO Congress 2012
Session Poster presentation I
Topics Non-Small-Cell Lung Cancer, Locally Advanced
Presenter Ilknur Alsan Cetin
Authors I. Alsan Cetin1, Z. Akgün Cetinkaya1, P.F. Yumuk2, F. Dane3, G. Karaüç1, N. Sunnetci1, N..S. Turhal2, B.M. Atasoy1
  • 1Radiation Oncology, Marmara University, 34903 - Istanbul/TR
  • 2Medical Oncology, Marmara university, ıstanbul/TR
  • 3Medical Oncology, marmara university, ıstanbul/TR



To determine the incidence and prognostic factors of brain metastatsis in locally advanced non-small cell lung cancer (NSCLC) patients who were curatively treated.

Materials and methods

Curatively treated 136 patients with stage IIIA/ IIIB NSCLC between 1997-2011 were retrospectively reviewed. M/F: 112/24. Median age was 61 (36-82). Median Karnofsky Performance Scale was 80 (70-100). 61 patients (45%) were IIIA. Histology was adenocarcinoma in 27%, and squamous cell cancer in 54%. Seventy patients had concomitant or sequential chemoradiotherapy (CRT), 16% had radiotherapy (RT). All patients received platinum based chemotherapy. Median 60 Gy was administered with conformal RT. The ratio and time to brain metastasis were noted. Age, gender, stage, histology and surgery were examined as prognostic factors.


Median follow-up was 13 months (range, 2-61 months). Two-year survival rate was 31%. One-year incidence of brain metastasis was 28.7%. In univariate analysis showed that patients younger than 60 years of age had more brain metastases than older patients (36% vs 15%, p = 0.01). Brain was more frequently the first site of metastases in younger patients than >60years (22% vs 9%, p > 0.05). Histology also significantly effected the development of brain metastasis (43.2% in adenocarcinoma, 16.4% in epidermoid carcinoma, p = 0.004). On multivariate analysis, only age was found to be significant prognostic factor (p = 0.01)


Age and histology significantly effects development of brain metastasis in locally advanced NSCLC. Younger age was the only significant variable for brain metastasis.


All authors have declared no conflicts of interest.