1600P - Exploring the types of quality of life trajectories and related factors in advanced lung cancer patients - a 6 months longitudinal study

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Supportive Care
Lung and other Thoracic Tumours
Presenter Yeur-Hur Lai
Authors Y. Lai1, Y. Lee1, Y. Liao2, W. Liao3, C. Yu3, Y. Liu1, P. Yang3, J. Chan1
  • 1School Of Nursing, National Taiwan University, College of Medicine & Hospital, 100 - Taipei/TW
  • 2Department Of Nursing, Yuan-Pei University, Shing-Jui/TW
  • 3Department Of Internal Medicine, National Taiwan University Hospital, Taipei/TW



Quality of life (QOL) is one of the major outcomes to reflect lung cancer patients' general condition. However, the individually physical and psychological differences may affect and cause different types of QOL trajectories. The aims of this study were to (1) explore the potential types of QOL trajectories in advanced lung cancer patients during the first 6 month of diagnosis, and (2) identify factors related to each type of the QOL trajectories.


A prospective longitudinal study was conducted in a medical center in Taiwan. A total of 170 newly diagnosed non-operable lung cancer patients were recruited and completed 4 assessments during pre-treatment and 1, 3, 6 months from receiving treatments (T1-4, respectively). QOL trajectory was measured by the overall QOL item from the EORTC QLQ-C30. Physical function and symptoms, depression, uncertainty (about illness) land self-efficacy (level of confidence) in coping with cancer were assessed and analyzed as potential related factors of each QOL trajectory. We used Latent Class Growth Analysis (LCGA) to identify the types of QOL trajectory and their related factors.


Three types of QOL trajectories were identified. The first type of QOL type covered 41.8% of patients which represented a “declining form moderate level of QOL to lower QOL and then back to moderate levels of QOL “. The second type of QOL covered 19.6% of patients and represented “the relatively higher level of QOL declined to relatively lower level of QOL and then steadily back to moderate QOL“. The third type of QOL covered 39.6% of patients and represented “steadily moderate level of QOL“. The factors significantly related to the first type of QOL trajectory were physical function, pain, poor appetite, uncertainty, and self efficacy; pain, uncertainty and self-efficacy were related to the second type of QOL trajectory; and depression and uncertainty were related to the third type of QOL trajectory.


Based on the QOL trajectories and identified factors, the timely and tailoring interventions should be developed, applied to and tested for their clinical effectiveness in enhancing advanced lung cancer patients' QOL during the most distressful first 6 months of having lung cancer. Acknowledge This study is supported by National Health Research Institute (NHRI) in Taiwan.


All authors have declared no conflicts of interest.