39P - A tertiary care hospital based retrospective study evaluating epidemiology of lung cancers in a western state of India

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Cancer Aetiology, Epidemiology, Prevention
Lung and other Thoracic Tumours
Presenter Saurabh Samdariya
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors S. Samdariya, P. Bagri, P. Pareek, R. Kumawat
  • Radiation Oncology, All India Institute Of Medical Sciences(AIIMS), 342005 - Jodhpur/IN

Abstract

Background

Lung cancer is the most common cancer in men and 2nd common cancer affecting women worldwide. It constitutes 6.9 per cent of all new cancer cases and 9.3 per cent of all cancer related deaths in both sexes. Adenocarcinoma predominates among all other histologies of lung cancer. Recently epidermal growth factor receptor (EGFR) expression has opened a new gateway in the prognosis and management of adenocarcinoma of lung. This study has assessed the Epidemiological data of lung cancer patients.

Methods

A retrospective study of lung carcinoma patients were carried out. Patients visiting to Department of radiation oncology, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan, India from August 2013 to December 2015 were collected. Brief demographic and clinical details of histopathological diagnosis, staging. EGFR status of lung cancers were collected. Obtained parameters were evaluated by descriptive statistical analysis & presented in percentage. The use of EGFR targeted therapies was evaluated by extracting relevant information from the database of the hospital & case sheets of enrolled patients.

Results

A total of 133 patients of invasive lung cancers were found. The age of the patients ranged from 13 to 80 years. Males twice commonly affected than females (69% vs 31%). Majority (69%) were primary lung cancers. Majority were smoker (61%). small cell lung cancer constituted only 8% of all cases. Adenocarcinoma constituted 30% of total patients, which was lower than the world over incidence of 32%. EGFR overexpression was seen in 55% of the adenocarcinoma cases, which was significantly higher than world over incidence of 40%.

Conclusions

Our data demonstrates that adenocarcinoma is the leading subtype of lung cancer in western part of India. Owing to significantly higher number of EGFR positive adenocarcinoma in our part of country, detection of EGFR expression is of paramount importance. EGFR mutations are increasing in smokers. Research efforts should be in the direction to find early diagnostic, effective screening tools as well as better targeted therapies and chemotherapy molecules for advanced lung cancers.

Clinical trial identification

Legal entity responsible for the study

All India Institute of Medical Sciences, Jodhpur

Funding

All India Institute of Medical Sciences, Jodhpur

Disclosure

All authors have declared no conflicts of interest.