101PD - Preoperative nomogram for identifying invasive pulmonary adenocarcinoma in patients with pure ground-glass nodule: A multi-institutional study

Date 14 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Predictive models for chemo- and radiotherapy
Topics Non-Small-Cell Lung Cancer, Early Stage
Imaging, Diagnosis and Staging
Presenter yun She
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors Y.L. She
  • Thoracic Surgey, Shanghai Pulmonary Hospital, Tongji University, Shanghai, 200433 - Shanghai/CN

Abstract

Background

Pure ground-glass nodules (GGNs), most of them are early stage lung adenocarcinomas, showed an extremely good prognosis when completely resected, which has led to a re-evaluation of the treatment design.

Methods

A primary cohort of patients with pathologically-confirmed pulmonary solitary pure GGN after surgery at the Shanghai Pulmonary Hospital from January 2009 to September 2015 was retrospectively studied. A nomogram predicting solitary pure GGN was constructed based on independent risk factors of solitary pure GGN. Predictive performance was evaluated by concordance index (c-index) and calibration curve. During the study period, a validation cohort was included at another four hospitals in China.

Results

A total of 898 cases were included, in which 501 (55.8%) were preinvasive lesions and 397 (44.2%) were invasive lesions. In univariate analysis, lesion size (p 

Conclusions

We established and validated a novel nomogram that can identify IPAs from preinvasive lesions in patients with solitary pure GGN. This model may improve clinical trial design and help physicians to make a suitable management approach.

Clinical trial identification

Legal entity responsible for the study

Shanghai Pulmonary Hospital

Funding

N/A

Disclosure

All authors have declared no conflicts of interest.