373P - Synchronous or metachronous esophageal cancer is associated with a lower survival rate in patients with head and neck squamous cell carcinoma

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Oesophageal Cancer
Aetiology, Epidemiology, Screening and Prevention
Head and Neck Cancers
Presenter Hee Man Kim
Citation Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587
Authors H.M. Kim1, J.H. Lee1, S.J. Baek2
  • 1Internal Medicine, Yonsei University Wonju College of Medicine, 220701 - Wonju/KR
  • 2Head And Neck Surgery, Yonsei University Wonju College of Medicine, 220701 - Wonju/KR



It is well known that patients with head and neck squamous cell carcinoma (SCC) have a high incidence of synchronous or metachronsous esophageal SCC. This study attempted to investigate an effect of esophageal cancer on the survival of patients with head and neck cancer (HNC).


Of patients with HNC, those with pathologically-proven SCC were enrolled in Wonju Severance Christian Hospital, Wonju, Korea. All patients received esophagogastroduodenoscopy at the time of HNC diagnosis and at regular interval. Survival times were calculated by Kaplan-Meier analysis and compared by log rank test.


Between 2000 July and 2013 June, a total of 218 patients with HN SCC were analyzed with 202 men (92.7%) and a mean age of 64.3 ± 11.0. Esophageal SCC was diagnosed in 15 patients (6.5%) with a mean age of 61.7 ± 9.4 years and gastric neoplasm including tubular adenoma and adenocarcinoma was diagnosed in 13 patients (5.6%) with 66.2 ± 7.9 years, and both cancers were diagnosed in 1 patient (0.4%). The rate of synchronous and metachronous esophageal SCC was 6 (40%):9 (60%). The median follow-up time was 29.8 moths (0-149.4). The estimated survival times were 74.6 (95% CI: 65.3-83.9) of HNC without EC and 38.1 (95% CI 20.2-56.1) of HNC with EC (P = 0.042).rn

Table: 373P

Age61.7 ± 9.466.2 ± 7.969
Sex (M:F)14:113:01:0
Squamous cell carcinoma15 (100%)01
Tubular adenocarcinoma091
Tubular adenoma050
Upper2 (13.3%)0E
Middle8 (53.3%)7 (53.8%)rn
Lower5 (33.3%)5 (38.5%)S
Unknown01 (7.7%)rn


Esophageal SCC had a negative effect on a survival of patients with head and neck SCC.

Clinical trial indentification

Legal entity responsible for the study

Hee Man Kim


Yonsei University Wonju College of Medicine


All authors have declared no conflicts of interest.