1001P - Expression of calreticulin is a novel independent prognostic factor for oral squamous cell carcinoma

Date 09 October 2016
Event ESMO 2016 Congress
Session Poster display
Topics Head and Neck Cancers
Presenter Takanori Takenawa
Citation Annals of Oncology (2016) 27 (6): 328-350. 10.1093/annonc/mdw376
Authors T. Takenawa, K. Harada, T. Ferdous, Y. Ueyama
  • Oral And Maxillofacial Surgery, Yamaguchi University Graduate School of Medicine, 755-8505 - Ube/JP

Abstract

Background

We focused on Calreticulin (CALR) on the basis of proteomic differential display analysis data using the regressive murine fibrosarcoma cell clone QR-32 and the progressive malignant tumor cell clone QRsP-11, derived from QR-32. CALR is an endoplasmic reticulum luminal Ca2 + -binding chaperone protein. CALR is thought to affect the tumor behavior of various malignancies. The purpose of this study was to determine whether CALR expression could be a useful prognostic factor in patients with oral squamous cell carcinoma (OSCC).

Methods

CALR expression was investigated by immunohistochemistry in tissue samples from 111 patients with OSCC. The association between CALR expression and clinicopathological characteristics, and patient survival were analyzed.

Results

Immunohistchemical staining of CALR was observed in the cytoplasm of the cancer cells. Among 111 OSCC patients, high expression of CALR was observed in 44 patients (39.6%), whereas 67 patients (60.4%) showed low expression of CALR. Significant association was found between CALR expression and T classification (p = 0.0027), N classification (p = 0.0219), stage (p = 0.0013), and patient outcome (p = 0.0014). The 3-year survival rates of patients with CALR high- and low-expression tumors were 50.1% and 86.6% respectively, which was significantly different (p 

Conclusions

These results suggest that elevated expression of CALR might play an important role in the progression of OSCC and could be considered as a useful prognostic factor in patients with OSCC.

Clinical trial identification

Legal entity responsible for the study

Yamaguchi University Graduate School of Medicine

Funding

Grant-in-Aid from the Japanese Ministry of Education, Science and Culture

Disclosure

All authors have declared no conflicts of interest.