1059 - Anti oxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and...

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Supportive measures
Head and Neck Cancers
Presenter Dariush Moslemi
Authors D. Moslemi1, N. Babaee2, A. Moghaddamnia3, G. Mazdai4
  • 1Radiation Oncology, Babol University of Medical Sciences, 47176-47745 - Babol/IR
  • 2Department Of Oral Diseases, Babol University of Medical Sciences, 47176-47745 - Babol/IR
  • 3Department Of Pharmacology, Babol University of Medical Sciences, 47176-47745 - Babol/IR
  • 4Radiation Oncology, Laleh hospital, Tehran/IR


To determine the effect of Calendula officinalis flower extract mouthwash as gel formulation on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck and head cancers who were treated with radiotherapy or chemoradiotherapy were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group). The subjects were treated with telecobalt radiotherapy at conventional fractionation (2 Gy/fraction, five fractions weekly, 20–35 fractions within 4–7 weeks). Oropharyngeal mucositis was evaluated by two doctors (a radiation oncologist and a dentist), using the oral mucositis assessment scale (OMAS). The patients also received concurrent chemotherapy. Calendula mouthwash significantly decreased the intensity of OM compared to placebo at week 2 (score: 5.5 vs. 6.8, p = 0.019), week 3 (score: 8.25 vs. 10.95, p < 0.0001) and week 6 (score: 11.4 vs. 13.35, p = 0.031). Total antioxidant, polyphenol and flavonoid contents and quercetin concentration of the 1% extract were 2353.4 ± 56.5 µM, 76.66 ± 23.24, 313.40 ± 6.52 mg/g and 19.41 ± 4.34 mg/l, respectively. Calendula extract gel could be effective on decreasing the intensity of radiotherapy- induced OM during the treatment and antioxidant capacitiy may be partly responsibe for the effect.


All authors have declared no conflicts of interest.