377PD - A randomized controlled trial evaluating honey for radiation induced mucositis in head & neck cancer patients

Date 21 December 2015
Event ESMO Asia 2015 Congress
Session Supportive and palliative care
Topics Complications/Toxicities of Treatment
Head and Neck Cancers
Surgical Oncology
Radiation Oncology
Presenter Saurabh Samdariya
Citation Annals of Oncology (2015) 26 (suppl_9): 111-124. 10.1093/annonc/mdv531
Authors S. Samdariya1, P.K. Bagri1, P. Pareek1, D. Kumar2, A. Kumar3, H. Kauser4, S. Lewis5, C. Viswanathan6, A. Kadam6, R. Jawarappa6, I. Ahmed6
  • 1Radiation Oncology, All India Institute Of Medical Sciences(AIIMS), 342005 - Jodhpur/IN
  • 2Community Medicine & Family Medicine, All India Institute Of Medical Sciences(AIIMS), 342005 - Jodhpur/IN
  • 3Head And Neck Oncology And Ent, All India Institute Of Medical Sciences(AIIMS), 342005 - Jodhpur/IN
  • 4Radiotherapy, Basavatarakam Indo American Cancer Hospital and Research Institute, Hyderabad/IN
  • 5Radiation Oncology, Tata Memorial Hospital Centre, Mumbai/IN
  • 6Radiotherapy, Bangalore Medical College & Research Institute, Bangalore/IN



Radiation induced mucositis is one of the major cause of morbidity and treatment gaps of head and neck cancer patients receiving concomitant chemoradiation. Apart from imparting additional morbidity and economic burden to patients in the form of requiring parenteral analgesia, interruption of radiation therapy (RT) and/or hospitalization, parenteral or tube feeding, it also has significant negative impact on quality of life. This paper aims to study the role of honey in reducing oral mucositis in head and neck cancer patients receiving concomitant chemoradiation.


A Randomized controlled trial on seventy-eight subjects (forty in test group and thirty-eight in control group) was undertaken to study the effect of honey on oral mucositis, but the analysis of 69 patients was done as 9 patients (4 in test and 5 in control group) lost to follow up or left treatment in between the study. All patients were advised to do salt-soda & benzydamine mouth gargles alternatively every 3 hours. Test group patients additionally received 20 ml honey three times a day during entire course of radiation treatment till 3 months following RT completion.


All the patients in both the groups had no mucositis at presentation. As the treatment progressed, test group patients had delayed appearance of mucositis as well as the severity of mucositis was lesser in test group patients. Grade 3 mucositis was documented in 19.4% test group patients while 81.8% and 6% patients in control group had grade 3 and grade 4 mucositis respectively. Thereby patient receiving honey had lesser treatment gaps and significantly lesser mean overall radiotherapy treatment duration. (Mean OTT in test group was 49.61 days verses 53.81 days in control, p < 0.05).


Honey being a cheap, palatable and natural medicament can be used for decreasing radiation induced mucositis in cancer patients.

Clinical trial identification


All authors have declared no conflicts of interest.