904P - Similarities suggest a shared embryologic origin for pancreatic and ovarian mucinous tumors

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Ovarian Cancer
Pancreatic Cancer
Pathology/Molecular Biology
Basic Scientific Principles
Presenter intidhar Labidi-Galy
Citation Annals of Oncology (2014) 25 (suppl_4): iv305-iv326. 10.1093/annonc/mdu338
Authors I. Labidi-Galy1, K.M. Elias2, A.F. Vitonis2, J.L. Hornick3, L.A. Doyle3, M.S. Hirsch3, D.W. Cramer2, R. Drapkin1
  • 1Medical Oncology, Dana Farber Cancer Institute, 02215 - Boston/US
  • 2Obstetrics And Gynecology, Brigham's and Women hospital, 02215 - Boston/US
  • 3Pathology, Brigham's and Women hospital, 02215 - Boston/US



Mucinous ovarian tumors (MOT) are among the rarest epithelial ovarian tumors. Their cell of origin is still unknown. Recently, whole-exome sequencing studies highlighted molecular similarities between MOT and mucinous cystic neoplasms (MCN) of the pancreas. We questioned commonalities between these seemingly disparate tumors and its significance.


Clinical characteristics of a series of 287 MOT and 23 MCN were compared. Immunohistochemical (IHC) expression of 7 proteins (CK7, CK20, MUC2, CDX2, PAX8, ß-catenin and SMAD4) was analyzed in 21 MOT and 16 MCN. Microarray datasets (Affymetrix HU133) of 6 MCN, 8 MOT, 70 epithelial (non mucinous) ovarian tumors and 6 primordial germ cells (PGC) were obtained from previously published studies.


In our series, MCN occurred only in women, mainly young (<54 years), with similar characteristics to MOT patients (p = 0.12). Both MCN (37%) and MOT (57%) patients tended to be or have been smokers (p = 0.1). MOT and MCN tumors showed similar IHC profile and were more likely to be CK7 + CK20-MUC2-CDX2-. Unsupervised clustering of the different datasets is ongoing and will be presented at the ESMO annual meeting.


Clinical, morphological and molecular similarities between MOT and MCN suggest a common pathogenesis, potentially a shared precursor such as embryologic rests of PGCs that transiently stop in the pancreatic buds during early development in the human embryo.


All authors have declared no conflicts of interest.