P-048 - Novel treatment of locally advanced esophageal cancer

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Anticancer Agents
Oesophageal Cancer
Therapy
Biological Therapy
Presenter A. Taghizadeh
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors A. Taghizadeh, M. Fazl Ersi, A. Emadi
  • MUMS, Mashhad/IR

Abstract

Introduction

The aim of this pilot study was to evaluate the efficacy of induction chemotherapy plus concurrent chemoradiation with weekly Paclitaxel /carboplatin in Locally advanced squamous cell carcinoma (SCC) of the esophagus.

Methods

13 patients with Locally advanced squamous cell carcinoma (SCC) of the esophagus received induction chemotherapy with paclitaxel 50mg/m2 and carboplatin (auc = 2) for 4 weeks & then concurrent chemoradiation with 5040/180cgy in 5 weeks and same regimen of induction chemotherapy. After 4 to 6 weeks the patients refer to oncologic surgeon for R0 resection.

Results

13 patients with non-metastatic esophageal cancer were entered from Jan 2012 until Jan 2013. 46% of patients were male and 53% were female. The patients age range between 36-73 and all of them had Scc histology. CPR (complete pathologic response) was achieved in 10 (76%) of patients and partial response in 2 (15%) & near complete response in 1 (7%) of patients.

Conclusion

Preoperative induction plus concurrent chemoradiation with weekly Paclitaxel /carboplatin is a good option with improve PCR rate for Locally advanced squamous cell carcinoma (SCC) of the esophagus. Large trails are needed to confirm this study results.