637P - Systemic inflammation is associated with the density of immune cells in the tumor microenvironment of gastric cancer

Date 08 October 2016
Event ESMO 2016 Congress
Session Poster Display
Topics Gastric Cancer
Cancer Immunology and Immunotherapy
Presenter Yeonjoo Choi
Citation Annals of Oncology (2016) 27 (6): 207-242. 10.1093/annonc/mdw371
Authors Y. Choi1, J.W. Kim1, K.H. Nam2, J. Kim3, S. Ahn4, D.J. Park4, K. Lee3, H.S. Lee5, H. Kim4
  • 1Department Of Internal Medicine, Seoul National University Bundang Hospital, 463-707 - Seongnam-si/KR
  • 2Department Of Pathology, Inje University Haeundae Paik Hospital, Busan/KR
  • 3Department Of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si/KR
  • 4Department Of Surgery, Seoul National University Bundang Hospital, Seongnam-si/KR
  • 5Department Of Pathology, Seoul National University Bundang Hospital, Seongnam-si/KR

Abstract

Background

The neutrophil-lymphocyte ratio (NLR) and the prognostic nutritional index (PNI) are markers of systemic inflammation known to be useful prognostic indicators in the malignancy. However, no direct evidence has yet defined the influence of inflammation on the tumor microenvironment.

Methods

A total of 288 patients who underwent curative surgery for gastric cancer were included. Preoperative peripheral blood samples were used to analyze NLR and PNI. The optimal cut-off levels for NLR and PNI were defined using receiver operating characteristic curve analysis for survival (NLR = 2.7, PNI = 47.7). The densities of specific immune cells [CD3(+), CD4(+), CD8(+)] within the tumor microenvironment were measured in tumor microarrays by immunohistochemical analysis.

Results

There were 235 patients (81.6%) in low NLR and 53 patients (18.4%) in high NLR. Low PNI was identified in 117 patients (40.6%) and high PNI is in 171 patients (59.4%). CD3(+) and CD8(+) immune cell density were not associated with NLR and PNI. However, in high NLR group, CD4(+) immune cell density was significantly decreased compared to low NLR group (P 

Conclusions

In summary, NLR and PNI are associated with the density of CD4(+) immune cells in the tumor microenvironment, which leads to its prognostic values of systemic inflammation in gastric cancer.

Clinical trial identification

It is not clinical trial

Legal entity responsible for the study

Jin Won Kim

Funding

Seoul National University Bundang Hospital

Disclosure

All authors have declared no conflicts of interest.