573P - The incidence of post-transplant malignancies in kidney transplantation recipients in King Chulalongkorn Memorial Hospital: A single institute with...

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Cancer Aetiology, Epidemiology, Prevention
Presenter Suleepon Uttamapinan
Citation Annals of Oncology (2016) 27 (suppl_9): ix184-ix189. 10.1093/annonc/mdw603
Authors S. Uttamapinan1, P. Puapatanakul2, T. Rattananupong3, V. Sriuranpong1, N. Townamchai2, N. Parinyanitikul1
  • 1Division Of Medical Oncology, Department Of Medicine, Chulalongkorn University and the King Chulalongkorn Memorial Hospital, 10330 - Bangkok/TH
  • 2Division Of Nephrology, Department Of Medicine, Chulalongkorn University and the King Chulalongkorn Memorial Hospital, 10330 - Bangkok/TH
  • 3Department Of Preventive Medicine, Chulalongkorn University and the King Chulalongkorn Memorial Hospital, 10330 - Bangkok/TH

Abstract

Background

The development of post-transplant malignancies especially genitourinary (GU) in origin has been well established in kidney transplantation (KT) recipients. Several risk factors including type and duration of immunosuppressive drugs might be associated with increasing frequency of malignancy. However, little have been extensively reported in Thailand. The aim of this study was to evaluate the incidence of post KT malignancies and correlation to outcomes in Thai post KT patients.

Methods

Six hundred and fifty-one KT recipients at King Chulalongkorn Memorial Hospital between 1972 and 2015 were reviewed retrospectively. Incidence of each malignancy, clinical characteristics and survival outcomes between post-transplant malignancies and non-malignancies were also analyzed.

Results

During the 44-year period, the mean age was 42.5 years (range 30.9 - 54.1 years) with median follow-up of 70 months, yielding 4,274 patient-years at risk. De novo malignancies were observed in 34 patients (Incidence 5.2%, or 0.81 cases per 100 patient-years). The median time from KT to the onset of malignancy was 49 months. The most common malignancies was GU malignancy (15 patients, 44.1%), followed by hepatocellular carcinoma (5 patients, 14.7%), post-transplant lymphoproliferative disorder (4 patients, 11.8%) and other malignancies (10 patients, 29.4%), respectively. Among 15 GU cancer patients, the majority was transitional cell carcinoma (TCC) of ureter and bladder, but only one renal cell carcinoma was reported. GU malignancy developed earlier than non-GU malignancy (47.5 vs 120.6 months after KT, p = 0.015) and 8 out of 15 (53.3%) was diagnosed in the first 2 years after KT. KT recipients with malignancies showed higher mortality rate compared to those without malignancies. (38.2% vs 13.6%, p 

Conclusions

The incidence of post-transplant malignancies in KT recipients is comparable to previous different studies. GU malignancy in particular TCC of ureter and bladder is the most common cancer which occur early after transplantation. Effective pre-KT evaluation programs for cancer screening should be encouraged.

Clinical trial indentification

Legal entity responsible for the study

King Chulalongkorn Memorial Hospital

Funding

King Chulalongkorn Memorial Hospital

Disclosure

All authors have declared no conflicts of interest.