428P_PR - Domestic cooking fuel as a risk factor for lung cancer in women - A case control study

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Early Stage
Cancer Aetiology, Epidemiology, Prevention
Presenter Asmin Sha
Citation Annals of Oncology (2016) 27 (suppl_9): ix134-ix135. 10.1093/annonc/mdw592
Authors A. Sha
  • General Pathology, al iqbal hospital and research centre, 679386 - thrissur/IN

Abstract

Background

Tobacco smoking is the most common risk factor for lung cancer. But a significant proportion of lungcancer occurs in non-smokers. Indoor pollution due to domestic fuels has been recently implicated asa causative agent in lung cancer especially in women. We conducted a case control study to find outthe role of Domestic Cooking Fuel as a risk factor for Lung Cancer in Indian women.

Methods

In a case control study 67 women with proven lung cancer were recruited. Forty-six females having anon-malignant respiratory disease constituted the control group. The patients and controls wereasked about the exposure in various cooking fuels using a questionnaire.

Results

There were 50(74.6%) non-smokers and 17(25.4%) smokers among the female cancer cases(p = 0.016). Adenocarcinoma was the commonest histological type of malignancy (n = 26, 38.8%) in the whole group and was the predominant form in the non-smoking females. Tobacco smoking was the most important risk factor for lung cancer with OR of 4.87 (95% CI, 1.34-17.76). Among non-smokers out of all the cooking fuels the risk of development of lung cancer was highest for biomass fuel exposurewith an odds ratio of 5.33 (95%, CI 1.7-16.7). Use of mixed fuels was associated with a lesser risk(OR = 3.04, 95%, CI 1.1-8.38).

Conclusions

This study indicated that domestic cooking fuel exposure is an important risk factor in the causation of lung cancer among women in addition of exposure to tobacco smoke.

Clinical trial indentification

NOT APPLICABLE

Legal entity responsible for the study

N/A

Funding

Al Iqbal Hospital and Research Centre

Disclosure

All authors have declared no conflicts of interest.