432P - Survival pattern of non-metastatic non-small cell lung cancer (NSCLC) in the United States

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Locally Advanced
Aetiology, epidemiology, screening and prevention
Presenter Ahmed Meshref
Citation Annals of Oncology (2016) 27 (suppl_9): ix136-ix138. 10.1093/annonc/mdw593
Authors A. Meshref1, M. Mousa1, M. Ramadan2
  • 1Faculty Of Medicine, Suez Canal University, 00202 - Ismailia/EG
  • 2Faculty Of Pharmacy, Suez Canal University, 00202 - Ismailia/EG

Abstract

Background

Tumor size and lymph node infiltration are known to be prognostic factors in different stages of non-small-cell lung cancer (NSCLC), the aim of this study is to show the effect of different treatment modality with different stage on survival rate.

Methods

The data were obtained from all 18 SEER database registries which were used to identify patients diagnosed with non-metastatic non-small cell lung cancer between 1988-2003. Relative five-year survival was calculated & compared between patient according to American Joint Committee on Cancer 6th edition classification with surgical and/or radiation intervention for treatment.

Results

6133 patients in the SEER databases who met the selection criteria. 57.7% was male, 82.1% was white. 56.8% of the patient has the primary lesion in the upper lobe of the lung. According to American Joint Committee on Cancer 6th edition 45.1% of the patient had T4 stage and 47.9% had N2 stage. All T stages showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention only except T3 stage which showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention and radiation therapy. N0 and N1 stage showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention only but N2 showed significant difference of 5 years relative survival (P > 0.05) with surgical intervention and radiation therapy.

Conclusions

Surgical intervention alone has significant higher 5 years relative survival rate with most of stages of NSCLC. However radiation therapy will be needed with surgical intervention in T3 and N2 stages.

Clinical trial indentification

Legal entity responsible for the study

Ahmed Meshref

Funding

Ahmed Meshref

Disclosure

All authors have declared no conflicts of interest.