86IN - HPV elimination of cervical cancer: The novel options in vaccination and screening

Date 01 October 2012
Event ESMO Congress 2012
Session Evidence-based answers to critical questions on cancer screening and prevention
Topics Cervical Cancer
Aetiology, epidemiology, screening and prevention
Basic Scientific Principles
Presenter Jack Cuzick
Authors J. Cuzick
  • Centre For Epidemiology Mathematics And Statistics, Queen Mary University of London, EC1M 6BQ - London/UK


The recognition that infection with certain human papillomavirus (HPV) types is a necessary cause of cervical cancer has opened new fronts for the prevention of this disease. Primary prevention is now possible via immunization and secondary prevention has gained impetus with the availability of HPV DNA testing. Although universal vaccination of teenagers and young women is a desirable policy, even with high uptake a substantial reduction in the burden of cervical cancer is unlikely for at least 10–15 years. To achieve cost-effective reductions, screening and immunization must be considered as integrated approaches. Several novel options are possible. If the nonavalent vaccine proves to be effective, a screen and vaccine strategy in older women is attractive, and raises the possibility of virtually eliminating cervix cancer in 5-10 years. New approaches for triage following primary HPV-based screening are also being developed and promise to substantially reduce referrals for non-progressive infections. These include HPV typing, p16 and methylation of viral and human genes. Lastly, the use of self sampling is likely to increase in vaccinated women with less frequent HPV-based tests. New collection devices and transport media will be needed to facilitate this.


J. Cuzick: Advisory boards for Abbott, Becton-Dickinson, Roche, GenProbe, Qiagen, Glaxo Smith Kline, Merck.