34P - A retrospective analysis of the epidemiological and prognostic factors of non small cell lung cancer in an Egyptian tertiary referral center

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Aetiology, epidemiology, screening and prevention
Thoracic malignancies
Basic Scientific Principles
Presenter sara Abdelfattah
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors S.H. Abdelfattah, H.M. El Wakeel, W.R. Elghamry, M.M. Ezzeldin
  • Clinical Oncology And Nuclear Medicine, Ain Shams university Faculty of medicine, 98744 - Cairo/EG

Abstract

Background

Lung cancer is one of the commonest and most lethal cancers throughout the world. Among the subtypes of lung cancer, non-small cell lung cancer (NSCLC) is the most prevalent, accounting for 85% of all new cases. The epidemiological and pathological profile of the disease differs among various ethnicities and geographical boundaries. Therefore, the aim of this study was to analyse the current clinico-pathological profile and factors affecting survival of Egyptian NSCLC patients at the department of Clinical Oncology and Nuclear medicine in Ain Shams University hospitals.

Methods

All patients with pathologically proven primary NSCLC in the period from 2012 to 2014 were included for analysis. Data from records of 195 cases were available for clinicopathological evaluation during the study period. Treatment received and outcome was collected.

Results

The mean age at diagnosis of the study population was 59 years, Male to female ratio was 3.6:1, 71.2% of cases were current or x-smokers, 44.6% of patients had ECOG performance status 1. The most common symptom at presentation was dyspnea and right upper lobe was the most common tumor site. Adenocarcinoma was the most common histological subtype representing 62% of cases. Most common stage at diagnosis was stage IV (56.4%) and the most common site of metastasis was bones. Statistically significant improvement in overall survival rate and progression free survival rate was found in the following groups: female sex, PS 1 or 2, never smokers, grade II tumors, lower tumor size, less lymph nodal stations involvement, lower stage at diagnosis, single versus multiple metastatic sites and response to definitive treatment.

Conclusions

The present analysis suggested that lung cancer incidence in Egypt is less than most of the western countries. Patients presented at younger age compared to other areas of the world. Most of the patients had advanced disease at presentation. Adenocarcinoma was the most common histological subtype. Female sex, better performance status, never smokers, smaller tumors, less lymph nodal affection, earlier stage at diagnosis, fewer metastatic sites and response to definitive treatment have a statistically significant better OS and PFS.

Clinical trial identification

Legal entity responsible for the study

Ain Shams Hospitals

Funding

Ain Shams Hospitals

Disclosure

All authors have declared no conflicts of interest.