1034P - Study on association of polymorphism of CYP 450 2D6 with head and neck cancer and treatment response in patients receiving neoadjuvant chemotherapy...

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Head and Neck Cancers
Translational Research
Surgical Oncology
Basic Principles in the Management and Treatment (of cancer)
Therapy
Radiation Oncology
Presenter Divyesh Kumar
Authors D. Kumar1, M.C. Pant2, N. Jamal2, D. Parmar2, S. Kumar2, S. Singh2, M. Bhatt2
  • 1Dept. Of Radiotherapy, VMMC,safdurjung hospital, New Delhi/IN
  • 2Deptt Of Radiotherapy, VMMC,safdurjung hospital, new delhi - 110029/IN

Abstract

Aim of study

1.To study the association of genetic polymorphism in Cyp 2D6 in patients of locally advanced head and neck cancer. 2. Try to assess a correlation between this polymorphism & response to treatment. Need of the study- To find out a possible genetic level explanation for the different response achieved in patients with similar histopathology, stage, exposure to carcinogen & ethinicity undergoing similar treatment.

Material & method

A study comprising of 150 patients & 150 controls was done to analyse the association between polymorphs of Cyp 450 2d6 with Head & neck cancer and treatment response (TPF- > CTRT). Two cycles of TPF(paclitaxel-175 mg/m2 D1,cisplatin 35 mg/m2 D2-D3 and 5Fu 1gm/m2 D1-D3 ) were given followed by radiotherapy with concurrent cisplatin (40 mg/m2).The response to the treatment was assessed clinically, radiologically & by laryngoscopy- post treatment .Genotyping of the blood samples was done. Analysis of the association between genetic polymorphisms and risk of HNSCC was estimated by calculating crude odds ratio (OR). A p-value of <0.05 was considered statistically significant. The statistical analysis was performed with the SPSS software package (version 11.0 for Windows; SPSS Chicago, IL).

Results

1. Patients with Cyp 2D6*1 showed good response to the therapy given, while Cyp 2D6*4 and *10 were poor responders.

Conclusion

1. There is a strong association of polymorphs of Cyp 2D6 (*4 &*10) with occurrence of head and neck cancer. 2. Response to treatment (TPF- > CT + RT) is polymorph graded. Our study, thus provides an insight in to the concept of “Right therapy to the right patient” & may also explain to the fact that why, only some people are more prone to develop head and neck cancer despite the usage of tobacco,alcohol by so many people.

Disclosure

All authors have declared no conflicts of interest.