13P - Expression of Notch 1 and Notch 3 proteins in imprints of NSCLC: Correlation with prognostic factors

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Thoracic malignancies
Translational Research
Basic Principles in the Management and Treatment (of cancer)
Presenter Eleftheria Haini
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors E. Haini1, A.M. Athanassiadou2, A. Tsipis2, K. Hainis3, M. Gonidi4, P. Athanassiadou2
  • 1Pulmonary Department, Corfu General Hospital, 11524 - Corfu/GR
  • 2A' Pathology Department, Cytology Unit, National and Kapodistrian University of Athens, Athens/GR
  • 3Pulmonary Department, Corfu General Hospital, Corfu/GR
  • 4Cytology Laboratory, Corfu General Hospital, Corfu/GR

Abstract

Background

It has been demonstrated that Notch 1 and Notch 3 proteins may be involved in malignant transformation and development of various types of tumours. The aim of this study was to investigate the role of Notch 1 and 3 proteins as biomarkers of predicting the prognostic outcome for patients with NSCLC

Methods

Imprint lung cancer specimens were examined from 50 patients with NSCLC who underwent surgical resection. An immunocytochemical method was apply with the use of Notch 1 and Notch 3 antibodies. The expression was correlated with clinicopathological parameters.

Results

Overexpression of Notch 1 and Notch 3 proteins was observed in 52% (26/50) and 48% (24/50) of NSCLC. The expression of Notch 1 was significantly correlated with stage (p = 0.02) and grade. The expression of Notch 3 was associated with lymphnode status (p = 0.001) and the stage (p 

Conclusions

In conclusion coexpression of both proteins correlates with poorer prognosis, in patients with resected NSCLC. Furthermore Notch 3 presents as a more attractive prognostic biomarker for NSCLC compared with Notch 1.

Clinical trial identification

Legal entity responsible for the study

National & Kapodistrian University of Athens

Funding

National & Kapodistrian University of Athens

Disclosure

All authors have declared no conflicts of interest.