286P - Prognostic and predictive values of BI-RADS classification in breast cancer patients

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Staging procedures (clinical staging)
Breast Cancer
Basic Principles in the Management and Treatment (of cancer)
Imaging
Presenter Yao-Lung Kuo
Authors Y. Kuo1, L. Cheng2, T. Chang1
  • 1Surgery, National Cheng Kung University, 704 - Tainan/TW
  • 2Radiology, National Cheng Kung University, 704 - Tainan/TW

Abstract

Objective

The goal of this study is to determine the prognostic and predictive values of the Breast Imaging Reporting and Data System (BI-RADS) classification in breast cancer patients.

Patients and methods

1045 patients with breast cancer were disgnosed between January 1, 1999, and December 31, 2007, and 512 (48.9%) of them were classified as BI-RADS 5. Overall survival and disease-free survival were estimated with the Kaplan-Meier method and compared across the two groups (BI-RADS 5 versus BI-RADS 0-4) using the log-rank test. Univariate and multivariate analyses were used to identify the prognostic factors.

Results

The median follow-up time was 87.8 months. Laplan-Meier analysis showed a significant difference between the two subgroups in five-year overall survival (p < 0.0001) and five-year disease-free survival (p < 0.0001). On multivariate analysis, the BI-RADS mammographic findings, lymph node status, HER-2 status, and tumor grade were significant factors related to five-year overall survival and disease-free survival.

Conclusion

The BI-RADS classification is a reliable prognostic and predictive factor. Taiwanese breast cancer patients with BI-RADS 5 mammographic finding showed a higher relapse rate than patients with BI-RADS 0-4 mammographic finding.

Disclosure

All authors have declared no conflicts of interest.