P-094 - FDG PET/CT as a preoperative staging modality for early gastric cancer

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Gastric Cancer
Staging procedures (clinical staging)
Basic Principles in the Management and Treatment (of cancer)
Imaging
Presenter H.W. Oh
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors H.W. Oh1, S. Kim2, H.J. Lee1
  • 1Chosun University, Gwangju/KR
  • 2Chosun University, Gwangju/

Abstract

Introduction

The purpose of this study was to evaluate the usefulness of FDG PET/CT as a preoperative nodal staging modality for early gastric cancer.

Methods

between January 2006 and December 2014, 230 patients who were diagnosed with early gastric cancer (T1 stage) after a gastrectomy were evaluated retrospectively. FDG uptake values were represented by maximal standardized uptake value (SUVmax). The clinicopathologic factors and SUVmax of PET/CT were assessed as predictors for lymph node metastasis.

Results

The overall rate of lymph node metastasis was 9.6% (22/230). In 39.6% patients (91/230), primary tumors were not revealed on PET/CT scan. Mean SUVmax was 4.6 ± 1.7 in the significantly expressed group (168/230). In 168 patients, the cutoff value of nodal metastasis was 5.75 (sensitivity = 52.9%, specificity = 86.9%). Invasion of submucosa (OR = 5.3), >2cm (OR = 1.7) and expression of lymphovascular invasion (OR = 7.2) were found as a prognostic factor for nodal metastasis in 230 patients (p<0.05). In significantly expressed patients (168/230) on PET/CT scan, >5.75 SUVmax (OR = 5.6), >2cm (OR = 7.1) and expression of lymphovascular invasion (OR = 8.9) were found as a prognostic factor for nodal metastasis (p < 0.05).

Conclusion

The FDG-PET-positive early gastric cancers are significantly associated with a nodal metastasis.