224PD - Predictors for recurrence after initial clinical complete response to definitive chemoradiotherapy in esophageal squamous cell carcinoma patients

Date 18 December 2016
Event ESMO Asia 2016 Congress
Session Gastrointestinal tumours
Topics Anti-Cancer Agents & Biologic Therapy
Oesophageal Cancer
Presenter Yin Kai Chao
Citation Annals of Oncology (2016) 27 (suppl_9): ix68-ix85. 10.1093/annonc/mdw582
Authors Y.K. Chao1, H. Chang2, C.K. Tseng3
  • 1Thoracic Surgery, Chang Gung Memorial Hospital-Linkou, 333 - Taoyuan/TW
  • 2Dept Hematology-oncology, Chang Gung Memorial Hospital-Taipei, 105 - Taipei/TW
  • 3Deparment Of Radiation Oncology, Chang Gung Memorial Hospital-Linkou, 333 - Taoyuan/TW

Abstract

Background

Definitive chemoradiotherapy(dCRT) is a curative treatment option for esophageal cancer and could be an alternative to esophagectomy. However, due to lack of effective diagnostic methods for the response evaluation, some patients who actually harbor residual disease after dCRT were falsely diagnosed as clinical complete response(cCR) and eventually exhibit relapse. The purpose of this study was to investigate the pattern, timing and risk factors for recurrence after cCR in esophageal squamous cell carcinoma(ESCC) patients after dCRT.

Methods

Patients who had clinical Stage I–III ESCC and achieved cCR after dCRT between 2001 and 2015 were retrospectively analyzed. Factors associated with recurrence were analyzed using univariate and multivariate analyses. Local recurrence(LR) included the primary tumor while regional and distant recurrence was defined as non-local recurrence(non-LR).

Results

There were 128 cCR patients with the mean age of 60.2(range: 36∼83). After a mean follow-up of 42 months, we identified 71(55.5%) recurrences (44 LR and 27 non-LR). LRs occurred significantly earlier then non-LRs.(Mean: 233 days versus 467 days, p = 0.012). More than 90% LR were detected within 2 years compared with 3 years for non-LR. By multivariate analyses, patient age

Conclusions

More than 50% of patients who achieved cCR after dCRT developed disease recurrence. Variables related to LR were: patient age

Clinical trial indentification

Legal entity responsible for the study

N/A

Funding

Chang Gung Memorial Hospital, Linkou

Disclosure

All authors have declared no conflicts of interest.