155P - PD-L1 polymorphism can predict clinical outcomes of non-small cell lung cancer patients treated with first-line paclitaxel–cisplatin chemotherapy

Date 15 April 2016
Event European Lung Cancer Conference 2016 (ELCC) 2016
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Non-Small-Cell Lung Cancer, Metastatic
Translational Research
Presenter Sook Kyung Do
Citation Journal of Thoracic Oncology (2016) 11 (supplement 4): S57-S166. S1556-0864(16)X0004-4
Authors S.K. Do1, S.Y. Lee2, J.E. Choi3, M.J. Hong3, J.H. Lee4, J.Y. Park2
  • 1Department Of Biochemistry And Cell Biology, Kyungpook National University, 700-422 - Daegu/KR
  • 2Department Of Internal Medicine, Kyungpook National University School of Medicine, Daegu/KR
  • 3Cell And Matrix Research Institute, Kyungpook National University School of Medicine, Daegu/KR
  • 4Departments Of Biochemistry And Cell Biology, Kyungpook National University School of Medicine, Daegu/KR

Abstract

Background

This study was conducted to investigate whether polymorphisms of genes involved in immune checkpoints can predict the clinical outcomes of patients with advanced stage non-small cell lung cancer (NSCLC) after 1st line paclitaxel-cisplatin chemotherapy.

Methods

A total of 379 NSCLC patients were enrolled. Twelve single nucleotide polymorphisms (SNPs) of PD-1, PD-L1, and CTLA-4 genes were selected and genotyped. The associations of SNPs with chemotherapy response and overall survival (OS) were analyzed.

Results

Among the 12 SNPs investigated, PD-L1 rs2297136T>C and rs4143815C>G were significantly associated with clinical outcomes after chemotherapy. The rs2297136T>C was significantly associated with both better chemotherapy response and better OS, and the rs4143815C>G had a significantly better response to chemotherapy. Consistent with the individual genotype analyses, rs2297136C-rs4143815G haplotype (ht4) carrying variant alleles at both loci was significantly associated with better chemotherapy response and OS compared with combined other haplotypes. Patients with at least one ht4 had significantly better chemotherapy response and OS compared to those without ht4.

Conclusions

PD-L1 rs2297136T>C and rs4143815C>G polymorphisms may be useful for the prediction of clinical outcome of 1st line paclitaxel-cisplatin chemotherapy in NSCLC. Further studies are needed to confirm our findings and to understand the role of PD-L1 in the chemotherapy outcome of NSCLC patients.

Clinical trial identification

N/A

Legal entity responsible for the study

Kyungpook National University

Funding

Ministry of Health & Welfare

Disclosure

All authors have declared no conflicts of interest.