368P - Influence of pre-RT haemoglobin levels on mucositis in locally advanced head and neck squamous cell carcinoma treated with concurrent chemo radiation

Date 17 December 2016
Event ESMO Asia 2016 Congress
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Complications of Treatment
Head and Neck Cancers
Surgery and/or Radiotherapy of Cancer
Presenter Karthikeyan Perumal
Citation Annals of Oncology (2016) 27 (suppl_9): ix112-ix122. 10.1093/annonc/mdw587
Authors K. Perumal1, R.K. Narayanasamy2, M. Sekhar2, S. Thyagarajan2, B. Ramakrishnan3
  • 1Radiation Oncology, Apollo Speciality Hospital, 600035 - Chennai/IN
  • 2Radiotherapy, Rai CBCC Cancer Center, 600095 - Chennai/IN
  • 3Biostatistics, Apollo Speciality Hospital, 600006 - Chennai/IN

Abstract

Background

Oral mucositis is one of common complication during chemoradiation of locally advanced head and neck squamous cell carcinoma (HNSCC). We prospectively analysed the role anaemia in patients having mucositis and is severity.

Methods

120 HNSCC (T3-T4a, N1-N2c) patients undergoing chemoradiation were prospectively evaluated for influence of Pre-RT haemoglobin on mucositis. All patients were in locally advanced disease stage III –IV. Sub-sites included were oral cavity, ororphaynyx, hypopharynx & laynyx. All patients received weekly inj.Cisplatin 40 mg/m2) along with radiation to a total dose of 66Gy to PTV. All patients were evaluated weekly by clinical examination for grade of mucositis and hemogram.

Results

Our population was characterized by a mean age of 55±10.7 years (range: 27-69), 85 were males and 35 females with a performance status of ECOG 1-2. The mean pre-RT haemoglobin was calculated (using ROC) as 10.3 g/dl. Among 120 patients 56 had grade 2 mucositis (48 were >10.3g/dl and only 8 were 10.3g/dl and 47 were 

Conclusions

Lower pre-RT haemoglobin level of 

Clinical trial indentification

Legal entity responsible for the study

N/A

Funding

Rai CBCC Center

Disclosure

All authors have declared no conflicts of interest.