Prognostic Index for CNS Lymphoma

A prognostic tool for distinguishing risk groups in immunocompetent patients with primary CNS lymphomas (PCNSL). This tool is based on data from 378 PCNSL patients treated at 23 cancer centres from five different countries.

Risk factors for the Definition of the Prognostic Index of the IELSG

General Index Parameter Remarks
1 Age > 60y None
1 PS 2-4 ECOG Performance Score
1 Serum LDH elevated above upper normal
1 Cerebrospinal fluid protein elevated above upper normal
1 Deep structures involved basal ganglia, corpus callosum, brain stem, or cerebellum
5 Maximum Score NOT evaluated for HIV+

Risk Groups of the IELSG Index

# of Risk Factors - General index Risk Group
0 - 1 1 = low
2 - 3 2 = intermediate
4 - 5 3 = high

Reprinted with permission. ©2008 American Society of Clinical Oncology. All rights reserved. Ferreri AJM et al: Prognostic Scoring System for Primary CNS Lymphomas: The International Extranodal Lymphoma Study Group Experience J Clin Oncol Vol.21 (2), 2003: 266-272.

Last update: 07 December 2008