Skin Changes

What do the skin reactions look like and where are they likely to appear?

Skin reactions can have different appearances, some of which are described below.

Typical pimples and redness

They may look like acne (but they are not).

Typical pimples and redness

You may have pimples, redness or itching; sometimes the skin may become sensitive.


There can be painful cracks in the skin of fingers and toes – mainly on the tips, the nail folds and over the knuckles. If left untreated, these cracks may bleed.

Nail bed inflammation

You may experience inflammation around the fingernails and toenails.

Facial hair changes

Facial hair (mainly eyebrows, eyelids, female upper lip, chin) may grow thicker and longer.

Skin colour changes

Some areas of skin may change colour slightly, but will return to normal once treatment stops.

Before Skin Treatment



After Skin Treatment

Cracks improved

Inflammation improved

All images provided with courtesy of Prof. Dr. Siegfried Segaert (University Hospital Leuven, Leuven, Belgium). © 2010 All rights reserved.

Last update: 10 May 2009