Fluorescence In Situ Hybridisation

Previous Page   Next Page


The disadvantages of FISH for detecting NTRK gene fusions are summarised in the following table.

Table 27: Disadvantages of FISH for Testing for NTRK Gene Fusions

  • Multiple tests are required as most commercial labs perform single gene, break-apart FISH
  • DNA level rearrangements are not confirmed to be transcribed (RNA) or expressed (protein) fusions (e.g. may detect ‘passenger’ alterations)
  • Requiresthat the target gene is known

« Previous Page Next Page »

Last update: 24 June 2019