DDR in Health and Disease

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The DDR network of proteins, which directly or indirectly sense, signal and/or repair DNA damage, plays a role in various normal physiological processes, including immune receptor diversity, production of gametes for sexual reproduction, telomere homeostasis, replication fidelity, and aging [1, 2].

Click on the links below to find out more about DNA damage and DNA repair mechanisms.

References

  1. Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461: 1071-1078.
  2. Jeggo PA, Pearl LH, Carr AM. DNA repair, genome stability and cancer: a historical perspective. Nat Rev Cancer 2016; 16: 35-42.