Tumor budding is associated with low expression of miRNA-148a and miRNA-625-3p in colorectal cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter E. Baltruskeviciene
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors E. Baltruskeviciene1, D. Schveigert1, U. Mickys2, K. Suziedelis1, E. Aleknavicius1
  • 1National Cancer Institute, Vilnius, Lithuania, /
  • 2National Pathology Center, Vilnius, Lithuania, /

Abstract

Tumor budding indicates the presence of individual cells and small clusters of tumor cells at the invasive front of carcinoma. It visually represents epithelial-mesenchymal transition (EMT), which is one of the principal ways by which cancer cells achieve invasive growth and metastases. Tumor budding is associated with more invasive phenotype, distant metastases and has been determined as independent prognostic factor in stage II colon cancer, but its role in metastatic setting is still not clear. Recent data has shown that miRNA-148a and miRNA-625-3p are involved in negative regulation of genes crucial in EMT and play important role in carcinogenesis and progression of colorectal cancer as well as in prediction of treatment efficacy. The aim of our study was to evaluate expression of miRNA-148a and miRNA-625-3p in tumor tissue and its association with clinical and pathological factors (including tumor budding) and prognostic significance.