The role of Angiotensin II subtype IA receptor on liver metastasis formation

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter Y. Shimizu
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors Y. Shimizu1, H. Amano2, W. Koizumi3, M. Majima2
  • 1Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara, Japan, /
  • 2Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Japan, /
  • 3Department of Gastroenterology, Kitasato University School of Medicine, Sagamihara-city, Japan, /

Abstract

Hepatic metastatic disease from colorectal cancer is a significant clinical problem. The 5-year survival rate of colorectal cancer patients with liver metastasis is reported to be less than 20%. Though surgical resection, chemotherapy and targeted therapy are performed against liver metastasis, treatment outcome is not satisfied. Renin Angiotensin System (RAS) involved in growth and progression of several tumor invasion and metastasis. It was reported that the angiotensin convert enzyme inhibitor (ACE inhibitor) suppressed colorectal cancer liver metastasis but the precise mechanism is not well understood. The objective of this study is to evaluate the role of angiotensin subtype receptor 1A on formation of liver metastasis in colorectal cancer.