Suppression of lipocalin-2 promotes the epithelial-to-mesenchymal transition in human colorectal cancer cells

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter S.L. Kim
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors S.L. Kim, S.W. Kim, Y.R. Park
  • Chonbuk National University Hospital, Jeonju, Republic of Korea, /

Abstract

Lipocalin-2 (LCN2) also known as neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa glycoprotein purified from neutrophil granules and it is observed in a wide spectrum of solid tumor cells including colorectal cancer (CRC). However, its functional roles and molecular mechanisms in CRC remain to be clarified. In this study, we investigated whether Lcn2 is associated with the epithelial-mesenchymal transition (EMT) in CRC and to explain the underlying signaling pathway.