Radioembolization (SIRT) as a Consolidation Treatment in Colorectal Liver Metastases after First Line Chemotherapy: Efficacy Safety

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter E. Cortesi
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors E. Cortesi1, G. Masi2, M. Mancini3, S. Caponnetto3, F. Urbano3, C. Mosillo3, S. Scagnoli3, E. Notarianni4, G. Pelle5, C. Vivaldi6, A. Falcone6, R. Cianni7
  • 1U.O. Oncologia Universitaria – Università “Sapienza” di Roma, Ospedale “Policlinico Umberto I”, Roma, Italy, /
  • 2U.O. Oncologia Medica 2, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori, Pisa, Italy, /
  • 3Sapienza University of Rome, Rome, Italy, /
  • 4Santa Maria Goretti Hospita Latina, Latina, Italy, /
  • 5Santa Maria Goretti Hospital Latina, Latina, Italy, /
  • 6Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, /
  • 7Diagnostic and Interventional Radiology Department, Santa Maria Goretti Hospital, Latina, Italy, /

Abstract

There are several locoregional liver-directed treatment options available for patients with unresectable liver metastases. One such liver-directed treatment is radioembolization (SIRT) with yttrium-90 (90-Y) microspheres. The data from SIRFLOX-study show that addition of SIRT using Y-90 microsphere to FOLFOX-based first line chemotherapy in patients with liver dominant metastases did not improve overall PFS but achieved a 7.9 months improvement in median PFS in the liver, representing a 31% reduction in risk of disease progression in the liver with no negative impact on duration of systemic therapy. Adverse events ≥ grade 3 were noted in 85.4 %. Most common toxicities were hematologic (51.2%) and gastrointestinal (32.9%), including gastric ulcer 2.4%. While in the SIFLOX study SIRT was given in combination with the first cycle of Folfox, we propose that SIRT should be given as a consolidation treatment after first line chemotherapy.