Prognostic significance of the frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter M. Kupec
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors M. Kupec1, J. Dvorak2, D. Hadzi Nikolov3, L. Dusek4, A. Filipova5, I. Richter6, D. Buka7, A. Ryska8, J. Mokry9, S. Filip7, B. Melichar10, T. Buchler11, J. Abrahamova2
  • 1Dept. of Oncology, Thomayer Hospital, Prague, Czech Republic, /
  • 2Department of Oncology, Thomayer Hospital, Prague, Czech Republic, /
  • 3Department of Pathology, Charles University Medical School and University Hospital, Hradec Kralove, Czech Republic, /
  • 4Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic, /
  • 5Department of Medical Biochemistry, Charles University Medical School, Hradec Kralove, Czech Republic, /
  • 6Department of Oncology, Regional Hospital Liberec, Charles University Medical School, Hradec Kralove/Liberec, Czech Republic, /
  • 7Department of Oncology and Radiotherapy, Charles University Medical School and University Hospital, Hradec Kralove, Czech Republic, /
  • 8Department of Pathology, Charles University Medical School and Teaching Hospital, Hradec Kralove, Hradec Králové, Czech Republic, /
  • 9Department of Histology and Embryology, Charles University Medical School, Hradec Kralove, Czech Republic, /
  • 10Department of Oncology, Palacky University Medical School and Teaching Hospital, Olomouc, Czech Republic, /
  • 11Department of Oncology, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic, /

Abstract

The primary cilium is a solitary, sensory, immotile microtubule-based structure that arises from the centrosome and is projected from the surface of most human cell types. It has been hypothesized that primary cilia could serve as a tumor suppressor organelle. The objective of this pilot study was to investigate the presence and frequency of primary cilia in cells of small bowel and colorectal adenocarcinoma originating from all anatomical parts of small intestine, colon and rectum and to evaluate the prognostic significance of their frequency.