Prognostic significance of cyclin D1 and p21 (WAF1/CIP1) in Gastric Cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter V. Michalaki
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors V. Michalaki1, T. Theodosopoulos2, N. Dafnios3, A. Vezakis3, E. Karvouni4, C. Papadimitriou5
  • 1Areteion Hospital University of Athens, Athens, Greece, /
  • 2Department of Surgery Areteion Hospital University of Athens, Athens, Greece, /
  • 3Department of Surgery Areteion Hospital, Athens, Greece, /
  • 4Histopathology Department, Athens, Greece, /
  • 5Oncology Unit Areteion Hospital University of Athens, Athens, Greece, /

Abstract

The deregulation of cyclin, cyclin-dependent kinases (CDKs) and their inhibitors could have a crucial role in the development of diverse human cancers. Alterations in cell cycle regulators and subsequent deregulation of the cell cycle are frequently involved in tumorigenesis and/or tumor progression. The aim of our study was to detect the abnormal expression of cyclin D1 and p21 (WAF1/CIP1) in gastric carcinoma and investigate its clinicopathologic significance.