Parthenolide suppresses hypoxia induced angiogenesis and epithelial-mesenchymal transition by regulating hypoxia inducible factor 1 α signaling in...

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter S.L. Kim
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors S.L. Kim, S.W. Kim, Y.R. Park
  • Chonbuk National University Hospital, Jeonju, Republic of Korea, /

Abstract

Activation of hypoxia-inducible factor 1 α (HIF-1α) is frequently observed in solid tumors and associated with numerous pathophysiological processes, including of epithelial-mesenchymal transition (EMT). We previously found that parthenolide (PT), a strong nuclear factor-?B (NF-?B) inhibitor, has recently been demonstrated to be a promising anticancer agent, promoting apoptosis of human colorectal cancer (CRC). Herein, we explored a new molecular mechanism of PT for HIF-1α and HIF-1 α contributing to EMT by NF-kB inhibition.