Outcomes with watch-and-wait after pelvic radiotherapy for rectal cancer in East Kent

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter M. Sridharan
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors M. Sridharan1, R. Raman2, A. Edwards2
  • 1Leeds University, Maidstone, United Kingdom, /
  • 2Kent Oncology Centre, Canterbury, United Kingdom, /


Total mesorectal excision and selective use of preoperative pelvic radiotherapy has reduced rates of local recurrence in non-metastatic rectal cancer. Preoperative long-course chemoradiotherapy (LC-CRT) has been shown to improve the complete resection rate. A minority of patients are found to have a pathological complete response (pCR) after LC-CRT. There is growing experience with the use of LC-CRT or radiotherapy alone among patients who are unfit for or refuse definitive surgery. This may avoid or delay the physical and psychosocial morbidity of radical surgery. It is recommended that all patients are informed about the potential for a non-surgical option.