Molecular characterization of gastrointestinal stromal tumours (GISTs): the experience of Hassan II University Hospital- Fez; Morocco

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter D. Doumbia Hamidou
Citation Annals of Oncology (2016) 27 (2): 86-101. 10.1093/annonc/mdw201
Authors D. Doumbia Hamidou
  • Hassan II Hospital Center, Medical Oncology Department, Fès, Morocco, /

Abstract

Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the digestive tract. Mutational analysis for KIT and PDGFRA genes is currently a standard practice to confirm the diagnosis of GIST, and to predict sensitivity to molecular targeted therapy. Centralization of mutational analysis in a laboratory enrolled in an external quality assurance program and with expertise in the disease is recommended. In the present study, we report our local experience to implement a standard gene analysis procedure for successful GIST mutation analysis and provide the preliminary results on the molecular characterization of GISTs in Moroccan population.