Maintenance chemotherapy or observation alone following gemcitabine-platinum combination palliative chemotherapy in locally advanced and/or metasta...

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter R. Pinninti
Citation Annals of Oncology (2016) 27 (2): 102-117. 10.1093/annonc/mdw200
Authors R. Pinninti1, V. Ostwal2, A. Ramaswamy1, S. Banavali1
  • 1Tata Memorial Hospital, Mumbai, India, /
  • 2Tata Memorial Centre, Mumbai, India, /

Abstract

The concept of maintenance chemotherapy was successful in metastatic colorectal cancers. This has not been well studied in other gastrointestinal cancers. The drug holiday or treatment free period is usually standard practice post 6 to 8 cycles of palliative chemotherapy in locally advanced and/or metastatic gallbladder cancer. We treat large number of gall bladder cancers which are bulky and associated with extensive metastatic disease burden. The drug holiday is usually associated with early progression and rapid clinical deterioration of performance status of the patient. This leads to failure in considering any other therapy. It is imperative to optimize the existing chemotherapeutic drugs and protocols to effect the improvement in survival and as well as quality of life. We tested continuation of palliative chemotherapy till progression in locally advanced and/or metastatic gallbladder cancer through a retrospective analysis of the series of patients who were treated with Gemcitabine - Platinum combination.