Inhibitory effect of Lactobacillus helveticus SBT2171 on the proliferation of colorectal tumor cells and the action mechanisms

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter K. Baba
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors K. Baba1, K. Ukibe2, M. Yamashita2, Y. Matsubara3, H. Nakagawa3, T. Miyazaki4
  • 1Department of Probiotic Immunology, Institution for Genetic Medicine, Hokkaido University, Sapporo, Japan, /
  • 2Milk Science Institution, Megmilk Snow Brand Co., Ltd., Kawagoe, Japan, /
  • 3Department of Probiotic Immunology, Institution for Genetic Medicine, Hokkaido University, Sappro, Japan, /
  • 4Department of Probiotic Immunology, Institution for Genetic Medicine, Hokkaido Universtiy, Sapporo, Japan, /

Abstract

Lactobacillus helveticus SBT2171 (LH2171) is a lactic acid bacterium that inhibits excessive immune responses. We have reported that LH2171 shows inhibitory effects on proliferation of BJAB, a B lymphoma cell line, through reduction of phosphorylation level of c-Jun, a critical regulator of cell proliferation. On the other hands, TGF-beta1 is known to be a secreted protein which regulates cell proliferation. In this study, we investigated the effect of LH2171 on the proliferation of colorectal tumor cells and the action mechanisms.