Immunohistochemical Expression of LRG5 and CD44 in Colorectal Polyps and Adenocarcinomas: Implications for Carcinogenesis

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter D. Yildiz
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors D. Yildiz1, M. Balci2, S. Yildiz3
  • 1Kırıkkale University Medical Hospital, Department of Pathology, Kırıkkale, Turkey, /
  • 2Kırıkkale Medical University, Department of Pathology, Kırıkkale, Turkey, /
  • 3Kahramanmaras¸ Çag˘layancerit Public Hospital, Department of Family Medicine, Kahramanmaras/Kırıkkale, Turkey, /


Colorectal cancer is the fourth ranking cancer worldwide and exhibits two-fold increase in industrialized countries after the age of 40s. Although there are well defined colorectal carcinomas associated with familial syndromes, most of them are sporadic cancers with complex pathogenetic pathways. Although the precise mechanism is still not understood, they arise through a multistep process in which genetic and epigenetic alterations accumulate in a sequential order; so the better defined precursor lesions are adenomatous polyps. The aim of this study is to semiquantitatively detect presence of cancer stem cell related markers LGR5 and CD44 in hyperplastic and adenomatous polyps and also in colorectal carcinomas.