Gastrointestinal stromal tumors: Fifteen years of experience in a Portuguese Hospital Centre

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter S. Lopes
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors S. Lopes, H. Gouveia, M. Pinho, S. Oliveira, J. Cunha, J. Godinho, L. Faria Ana, J. Macedo, P. Santos
  • Centro Hospitalar de Entre o Douro e Vouga, Santa Maria da Feira, Portugal, /

Abstract

Gastrointestinal stromal tumors (GISTs) are rare, with an incidence of approximately 1.5/100.000 per year. The most common primary sites are stomach (about 60%) and small intestine (about 30%). The prognostic factors include: mitotic rate, size, tumor site and rupture. Most GISTs (95%) express KIT. Approximately 80% of GISTs have a mutation in the gene encoding the KIT receptor tyrosine kinase; another 5% to 10% of GISTs have a mutation in the gene encoding the related PDGFRA receptor tyrosine kinase. With this observational retrospective, we aim to define GISTs behavior and its association to immunohistochemical and histological features.