Dosing first cycle of chemotherapy in colorectal cancer: is BSA used for everybody?

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter E. Una Cidon
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors E. Una Cidon1, P. Alonso2
  • 1Oncology Department, Royal Bournemouth Hospital, NHS Foundation Trust, Bournemouth, United Kingdom, /
  • 2Clinical University Hospital, Valladolid, Spain, /

Abstract

Optimal doses of chemotherapy drugs are established through randomized clinical trials. In adult patients, chemotherapy drug dosing is based on the patient's estimated body surface area (BSA) and there is evidence that reductions from standard dose may compromise survival in the curative setting. However, many oncologists prefer to cap the BSA at 2.0m2 rather than use the estimated BSA. We have carried out an audit in our institutions to know further about our practices in patients with colorectal cancers in the adjuvant or neoadjuvant settings.