Comparative planning of volumetric modulated arc therapy versus intensity modulated radiation therapy and proton beam therapy in anal cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter J. Hansen
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors J. Hansen1, E. Wilken2, J. Petersen3, E. Serup-Hansen2, K.-. Spindler4
  • 1Aarhus University Hospital, Aarhus, Denmark, /
  • 2Herlev Hospital, Herlev, Denmark, /
  • 3Aarhus University Hospital, Department of Medical Physics, Aarhus, Denmark, /
  • 4Department of Oncology, Aarhus University Hospital, Aarhus, Denmark, /


Volumetric modulated arc therapy (VMAT) enables dynamic modulation of angular dose rate through changes in gantry speed, linear accelerator dose rate, and multileaf collimator motion. Consequently, treatment time is reduced compared to traditional fixed field IMRT, and VMAT is considered as a feasible option for anal cancer radiotherapy delivery. However, published data on a direct comparison on relevant parameters is sparse. This study aimed to evaluate VMAT compared to IMRT for definitive treatment of anal carcinoma regarding dose coverage and normal tissue exposure. Data were supplemented by data from experimental proton beam treatment plans.