Comparative molecular analyses of esophageal adenocarcinoma, esophageal squamous cell carcinoma, and gastric adenocarcinoma, and impact of molecula...

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter M. Salem
Citation Annals of Oncology (2016) 27 (2): 118-128. 10.1093/annonc/mdw198
Authors M. Salem1, J. Xiu2, W. El-Deiry3, S. Reddy2, P. Philip4, Z. Gatalica2, S. Khan5, C. Denlinger3, S. Mikhail6, B. Smaglo7, M. Pishvaian1, J. Hwang1, A. Shields4, J. Marshall1
  • 1Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA, /
  • 2Caris Life Sciences, Phoenix, Arizona, USA, /
  • 3Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA, /
  • 4Karmanos Cancer Center, Detroit, Michigan, USA, /
  • 5Georgetown University Hospital, Washington, District of Columbia, USA, /
  • 6OSU Comprehensive Cancer Center-James Cancer Hospital & Solove Research Institute, Columbus, Ohio, USA, /
  • 7Georgetown University, Washington, District of Columbia, USA, /

Abstract

Patients (pts) with gastroesophageal tumors have a poor prognosis and limited treatment options. Currently gastric tumors are treated differently from esophageal tumors. The effect of histological subtype on tumor molecular profile remains unknown. Here we aim to compare the molecular characteristics of esophageal adenocarcinoma (EAC), esophageal squamous cell carcinoma (ESCC), and gastric adenocarcinoma (GAC).