Comparative characteristics of somatic mutations in the KRAS gene in patients with colorectal cancer the South of Russia

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter O. Kit
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors O. Kit, D. Vodolazhsky, L. Vladimirova, K. Dvadnenko, E. Oleynikova, Y. Enin, D. Kutilin
  • Rostov Cancer Research Institute, Rostov-on-Don, Russia, /

Abstract

Colorectal cancer (CRC) takes one of the leading places in the structure of cancer incidence and mortality in the world. Application of monoclonal antibodies to EGFR has increased the overall survival in patients with wild-type KRAS metastatic CRC. There are no studies on the frequency of KRAS mutations and their association with clinical and pathological features of patients with CRC in the South of Russia though this territory has its own population of particular qualities. The aim of the research was to study the polymorphism of SNP somatic mutations in KRAS gene in CRC-tumor biopsies taken from patients in the South of Russia.