CCL2 expression is correlated with Snail expression and affects the prognosis of patients with gastric cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter J. Zhang
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors J. Zhang1, J. Zhang2, Y. Yan2, J. Wang3
  • 1The Second Department of Thoracic Surgery, First Affiliated Hospital, Medical School, Xi'an Jiaotong University, Xi'an, China, /
  • 2First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China, /
  • 3Department of Thoracic Oncosurgery, First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, China, /

Abstract

Aberrant expression of CCL2 has been reported in a variety of malignancies and is associated with adverse prognosis including gastric cancer (GC). CCL2 has been shown to play a critical role in recruiting monocytes/macrophages. Our previous study has shown high infiltration of tumor-associated macrophages influence poor prognosis in human GC patients and associate with the phenomenon of epithelial-mesenchymal transition (EMT). The Snail family of transcription factors are core inducers of EMT.