A phase II study of a combination treatment of alternate-day S-1 and lentinan as first-line chemotherapy for unresectable or recurrent gastric cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter S. Yoshino
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors S. Yoshino1, T. Nishimura2, K. Sakata2, S. Yoshida3, T. Furuya4, T. Yamamoto5, T. Kawaoka6, R. Shimizu7, T. Sato8, K. Matoba9, H. Morioka10, M. Iida1, N. Suzuki1, S. Takeda1, T. Ueno1, S. Hazama11, H. Nagano1
  • 1Yamaguchi University Graduate School of Medicine, Department of Gastroenterological, Breast and Endocrine Surgery, Ube, Japan, /
  • 2Shimonoseki Medical Center, Department of Digestive Surgery, Shimonoseki, Japan, /
  • 3Saint Hill Hospital, Ube, Japan, /
  • 4Kanmon Medical Center, Department of Surgery, Shimonoseki, Japan, /
  • 5Tsushimi Hospital, Department of Surgery, Hagi, Japan, /
  • 6Ube Industries Central Hospital, Department of Surgery, Ube, Japan, /
  • 7Ogori Daiichi General Hospital, Department of Surgery, Yamaguchi, Japan, /
  • 8Onoda Red Cross Hospital, Department of Surgery, Sanyo Onoda, Japan, /
  • 9Yawatahama City General Hospital, Department of Surgery, Yawatahama, Japan, /
  • 10Mine City Mitou Hospital, Department of Surgery, Mine, Japan, /
  • 11Yamaguchi University Department of Gastroenterological, Breast and Endocrine Surgery, Ube, Japan, /

Abstract

Treatment with S-1 plus cisplatin is a standard regimen for unresectable or recurrent gastric cancer. However, adverse events are commonly observed in this regimen, so S-1 monotherapy is one of the treatment option especially in elderly patients. Even in the S-1 treatment, the standard schedule of a 4-week daily administration followed by a 2-week rest frequently causes adverse events. We attempted an alternate-day therapy with S-1 plus antitumor polysaccharide lentinan to reduce the adverse events and to achieve long-term administration.